CBR1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comCBR1 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > CBR1(Gene name) > Human

CBR1 (Gene name),

Carbonyl reductase [NADPH] 1 (Protein name ), CBR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CBR1(CBR;CRN);

Protein name:

Carbonyl reductase [NADPH] 1;

Alternative:

NADPH-dependent carbonyl reductase 1;1.1.1.197;15-hydroxyprostaglandin dehydrogenase [NADP+]);1.1.1.189;Prostaglandin-E(2) 9-reductase);Prostaglandin 9-ketoreductase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

277

Sequence:

50:

100:

150:

200:

250:

277:

PVYLALLPPD | AEGPHGQFVS | EKRVEQW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:873

SMR:

P16152

UniGene:

Hs.88778

UniGene:

Hs.606200

Pfam:

PF00106

String:

P16152

MIM:

114830

STRING:

9606.ENSP00000290349

Uniprot:

P16152

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ELISA Kit for Human Carbonyl reductase [NADPH] 1

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E10192p

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ELISA Kit for Human Carbonyl reductase [NADPH] 1

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E10192r

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ELISA Kit for Human Carbonyl reductase [NADPH] 1

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E10192b

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96T

ELISA Kit for Human Carbonyl reductase [NADPH] 1

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E10192m

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ELISA Kit for Human Carbonyl reductase [NADPH] 1

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ELISA Kit for Human Carbonyl reductase [NADPH] 1

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E10192h

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96T

CLIA Kit for Human Carbonyl reductase [NADPH] 1

Cat.:

U10192m

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96T

CLIA Kit for Human Carbonyl reductase [NADPH] 1

Cat.:

U10192r

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96T

CLIA Kit for Human Carbonyl reductase [NADPH] 1

Cat.:

U10192h

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96T

CLIA Kit for Human Carbonyl reductase [NADPH] 1

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CLIA Kit for Human Carbonyl reductase [NADPH] 1

Cat.:

U10192b

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MSDS:

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Packing:

96T

CLIA Kit for Human Carbonyl reductase [NADPH] 1

Cat.:

U10192p

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Polyclonal Antibody for Human Carbonyl reductase [NADPH] 1

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P10192Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Carbonyl reductase [NADPH] 1

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P10192Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Carbonyl reductase [NADPH] 1

Cat.:

P10192Rb-m

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Monoclonal Antibody for Human Carbonyl reductase [NADPH] 1

Protein for Human Carbonyl reductase [NADPH] 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein."
Wermuth B. , Bohren K.M. , Heinemann G. , von Wartburg J.-P. , Gabbay K.H.
J. Biol. Chem.263:16185-16188(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
tissue: Placenta.
2.

"Induction of a human carbonyl reductase gene located on chromosome 21."
Forrest G.L. , Akman S. , Krutzik S. , Paxton R.J. , Sparkes R.S. , Doroshow J. , Felsted R.L. , Mohandas T. , Bachur N.R.
Biochim. Biophys. Acta1048:149-155(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
tissue: Mammary gland.
3.

"Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity."
Forrest G.L. , Akman S. , Doroshow J. , Rivera H. , Kaplan W.D.
Mol. Pharmacol.40:502-507(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
4.

"Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2."
Watanabe K. , Sugawara C. , Ono A. , Fukuzumi Y. , Itakura S. , Yamazaki M. , Tashiro H. , Osoegawa K. , Soeda E. , Nomura T.
Genomics52:95-100(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
5.

"Human fetal brain carbonyl reductases."
Terada T. , Mizobuchi H.
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal brain.
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
7.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Hippocampus.
9.

SeattleSNPs variation discovery resource
Submitted (2006-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT SER-131
10.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Skin.
13.

"Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase."
Krook M. , Ghosh D. , Stroemberg R. , Carlquist M. , Joernvall H.
Proc. Natl. Acad. Sci. U.S.A.90:502-506(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;N6-1-CARBOXYETHYLATION AT LYS-239
14.

"Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER)."
Gonzalez-Covarrubias V. , Kalabus J.L. , Blanco J.G.
Pharm. Res.25:1730-1734(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;FUNCTION
15.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"An unbiased cell morphology-based screen for new, biologically active small molecules."
Tanaka M. , Bateman R. , Rauh D. , Vaisberg E. , Ramachandani S. , Zhang C. , Hansen K.C. , Burlingame A.L. , Trautman J.K. , Shokat K.M. , Adams C.L.
PLoS Biol.3:E128-E128(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.24 ANGSTROMS) OF 2-276 IN COMPLEX WITH THE SYNTHETIC INHIBITOR HYDROXY-PP AND NADP;IDENTIFICATION BY MASS SPECTROMETRY;PARTIAL PROTEIN SEQUENCE;FUNCTION
18.

"Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct."
Bateman R. , Rauh D. , Shokat K.M.
Org. Biomol. Chem.5:3363-3367(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 2-277 IN COMPLEX WITH NADP AND FORMALDEHYDE-GLUTATHIONE ADDUCT;FUNCTION
19.

"Human carbonyl reductase 1 is an S-nitrosoglutathione reductase."
Bateman R.L. , Rauh D. , Tavshanjian B. , Shokat K.M.
J. Biol. Chem.283:35756-35762(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 2-277 IN COMPLEX WITH NADP;SUBSTRATE ANALOGS;FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
20.

"A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity."
Gonzalez-Covarrubias V. , Ghosh D. , Lakhman S.S. , Pendyala L. , Blanco J.G.
Drug Metab. Dispos.35:973-980(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-88;CHARACTERIZATION OF VARIANT ILE-88;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION

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